The city has several well known educational institutions.

Angel Mounds was a permanent settlement of the Mississippian culture from 1000 AD to around 1400 AD. The broad economic base of the region has helped to build an economy which is known for its stability, diversity, and vitality.

Four NYSE companies (ACW, BERY, LEAF, VVC) are headquartered in Evansville, along with the global operations center for NYSE company Mead Johnson.

Three other companies traded on the NASDAQ (ESCA, ONB, SCVL) are located in Evansville.

The city is home to public and private enterprise in many areas, as Evansville serves as the economic hub of the region.

As the state's third-largest city and the largest city in Southern Indiana, it is the commercial, medical, and cultural hub of Southwestern Indiana and the Illinois-Indiana-Kentucky tri-state area.

Situated on an oxbow in the Ohio River, the city is often referred to as the "Crescent Valley" or "River City".

As testament to the Ohio's grandeur, early French explorers named it La Belle Riviere ("The Beautiful River").

The area has been inhabited by various cultures for millennia, dating back at least 10,000 years.

There was a continuous human presence in the area that became Evansville from at least 8,000 BC by Paleo-Indians. The land encompassing Evansville was formally relinquished by the Delaware in 1805 to General William Henry Harrison, then governor of the Indiana Territory.

Archaeologists have identified several archaic and ancient sites in and near Evansville, with the most complex at Angel Mounds from about 900 A. French hunters and trappers were among the first Europeans to come to the area, using Vincennes as a base of operations. purchased about 441 acres and named it "Mc Gary's Landing".

In 1814, to attract more people, Mc Gary renamed his village "Evansville" in honor of Colonel Robert Morgan Evans.